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Meta-regression showed a significant difference was detected in the postvaccine response rate on the basis of prevalence of diabetes (regression coefficient, −0.06 95% CI, −0.10 to −0.02 P = .004). The overall immunogenicity rate of the dialysis group was 86% (95% CI, 81%-89%). Results A total of 32 studies were included. Subgroup analysis and meta-regression were conducted to identify the sources of heterogeneity. The secondary outcomes were pooled response rates in individuals receiving and not receiving dialysis.
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Main Outcomes and Measures The primary outcome was the pooled antibody postvaccine response rates in individuals with ESKD.
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Two independent reviewers conducted the literature search and extracted the data. Study Selection Studies that evaluated the immunogenicity rate according to the postvaccine antibody response rate in patients with ESKD receiving dialysis were selected.ĭata Extraction and Synthesis The meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Objective To assess immunogenicity rates in people with end-stage kidney disease (ESKD) receiving SARS-CoV-2 vaccines, explore postvaccination potential risk factors for nonresponse, and assess whether receiving dialysis is associated with different antibody response rates compared with the nondialysis population.ĭata Sources This systematic review and meta-analysis used articles from PubMed, Medline, and Embase published before July 30, 2021, as well as articles in the medRxiv preprint server. To date, the immune response of people receiving dialysis after SARS-CoV-2 vaccination has not been systematically discussed. Importance Adults receiving dialysis treatment have a higher likelihood of death when infected with SARS-CoV-2 than adults not receiving dialysis treatment.